Pyrimidine nucleosides
Research Products International Corp RPI 2'-Deoxycytidine Hydrochloride, 1 Gram
2'-Deoxycytidine Hydrochloride
![eMolecules 40733-27-5 | 3'-O-(Tbdms)thymidine | Combi-Blocks, Inc. | MFCD01631040 | 356.494 | C16H28N2O5Si | 97.000 | Cc1cn([C@H]2C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](CO)O2)c(=O)[nH]c1=O | 1g | 586075058](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502188243.JPG-250.jpg)
eMolecules 40733-27-5 | 3'-O-(Tbdms)thymidine | Combi-Blocks, Inc. | MFCD01631040 | 356.494 | C16H28N2O5Si | 97.000 | Cc1cn([C@H]2C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](CO)O2)c(=O)[nH]c1=O | 1g | 586075058
3'-O-(Tbdms)thymidine | Combi-Blocks, Inc. | 40733-27-5 | MFCD01631040 | 356.494 | C16H28N2O5Si | 97.000 | Cc1cn([C@H]2C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](CO)O2)c(=O)[nH]c1=O | 1g | 586075058
Medchemexpress LLC 2'-Deoxycytidine-5'-monophosphoric acid disodium (dCMP disodium) | 13085-50-2 | MFCD00069774 | 98.0% | 351.16 | 500 MG
2'-Deoxycytidine-5'-monophosphoric acid disodium (dCMP disodium) is an endogenous metabolite. This product is intended for research use only and is not for sale to patients.
- Endogenous metabolite
- For research use only
Medchemexpress LLC KTX-951 | 2573298-36-7 | 99.6% | 850.95 | 1 MG
KTX-951 is an orally active PROTAC degrader targeting IRAK4 and IMiD (Ikaros/Aiolos) substrates. It exhibits a Kd of 3.5 nM for IRAK4, with DC50 values of 13 nM, 14 nM, and 13 nM for IRAK4, Ikaros, and Aiolos, respectively. This compound also shows an IC50 of 35 nM for OCl-Ly10 CTG and demonstrates antitumor activity.
- Orally active PROTAC degrader
- Targets IRAK4 and IMiD (Ikaros/Aiolos) substrates
- Kd of 3.5 nM for IRAK4
- Molecular weight: 850.95
- Formula: C46H52F2N8O6
- Appearance: Solid, light yellow to yellow
- Purity: 99.60%
- Soluble in DMSO at 50 mg/mL (58.76 mM)
- Oral bioavailability in rats: 22% at 10 mg/kg
- Oral bioavailability in dogs: 57% at 10 mg/kg
Cayman Chemical 5-Bromo-2-deoxyurIdIn 1g
A thymidine nucleoside derivative commonly used to identify proliferating cells; intraperitoneal injection of BrdU can be used in combination with neuronal markers to detect adult neurogenesis in animal models; commonly used as a marker of proliferation of cancer cells in vitro
Research Products International Corp RPI 2'-Deoxycytidine Hydrochloride, 25 Grams
2'-Deoxycytidine Hydrochloride
Medchemexpress LLC Uridine, 2'-deoxy-4-thio- | 5580-20-1 | MFCD00058457 | 99.8% | 244.27 g·mol⁻¹ | C9H12N2O4S | 5 MG
4-Thio-2'-deoxyuridine is a sulfur-substituted deoxyuridine nucleoside analog supplied as a light-yellow solid and used as a research reagent in studies of DNA synthesis, nucleoside metabolism, and antitumor mechanisms. It is characterized for biochemical and cell-based experiments and provided with supporting analytical data.
- High purity (99.8%) for research applications.
- Sulfur-substituted nucleoside for incorporation and metabolism studies.
- Stable solid form with recommended low-temperature storage.
- Well-characterized molecular properties (C9H12N2O4S; 244.27 g·mol⁻¹).
- Available in small quantities suitable for laboratory-scale experiments.
Medchemexpress LLC 4-thio-2'-deoxyuridine | 5580-20-1 | MFCD00058457 | 99.8% | 244.27 g/mol | C9H12N2O4S | 100 MG
4-Thio-2'-deoxyuridine is a sulfur-substituted deoxyuridine nucleoside analogue used in biochemical and nucleic acid research, including studies of nucleic acid chemistry and incorporation into oligonucleotides. It has molecular formula C9H12N2O4S, molecular weight 244.27 g/mol, and a reported purity of 99.78%.
- Sulfur-substituted deoxyuridine analogue useful for nucleic acid studies.
- High reported purity (99.8%), suitable for analytical and synthetic applications.
- Available in multiple pack sizes for research-scale work.
- Provided with certificate of analysis and safety data sheet for quality and handling.
- Offered in solid form and as 10 mM DMSO solution for convenient use.
Medchemexpress LLC 2'-Deoxycytidine-5'-monophosphate | 1032-65-1 | 99.99% | 307.20 | 5 MG
2'-Deoxycytidine-5'-monophosphate (2'-Deoxycytidine-5'-monophosphoric acid) is an endogenous metabolite and a deoxynucleotide building block of DNA. It acts as a substrate of UMP/CMP kinase to form dCDP upon phosphorylation to dCTP, thereby supporting DNA biosynthesis.
- Endogenous metabolite
- Deoxynucleotide building block for DNA
- Substrate for UMP/CMP kinase
- Supports DNA biosynthesis
Medchemexpress LLC 2'-Deoxyuridine (standard) | 951-78-0 | 99.2% | 5 MG
2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine, intended for research and analytical applications. It is a brain-penetrant pyrimidines nucleotide associated with nervous system diseases. It can increase chromosome breakage and decrease thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine and an analogue of 5-ethynyl-2'-deoxyuridine, EdU. It reduces microglial activation and improves oxidative stress damage by modulating glycolytic metabolism on Aβ25-35-induced brain injury, making it promising for Alzheimer's disease (AD) research.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Passes the blood-brain barrier (BBB) in mice.
- Improves cognition and memory loss and attenuates hippocampal damage in Aβ25-35-induced mice models.
